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Funded Studies

Global Parkinson’s Genetics Program (GP2)

GP2 is a resource of the Aligning Science Across Parkinson's (ASAP) Initiative.

Study Rationale
A substantial proportion of risk for Parkinson’s disease (PD) is driven by genetics, and genetic links to PD have advanced disease understanding and therapeutic development. There is still much to learn about identified genetic risk factors as so much remains undiscovered. We know that not all people with PD-linked mutations develop the disease, and, in those who do, onset can be late in life, suggesting existence of protective genetic factors that prevent or delay disease. The path to further understanding the genetic architecture of PD requires working collaboratively to analyze samples from hundreds of thousands of people representing diverse backgrounds and disease experiences. Progress requires working openly and sharing data, processes, and results.

Aligning Science Against Parkinson’s (ASAP) has developed a strategic roadmap to collectively tackle field-wide challenges. Its three-part strategy aims to support meaningful, multidisciplinary collaboration; generate research-enabling resources; and democratize data. ASAP supports the Global Parkinson’s Genetics Program (GP2) in service of those goals. The findings and compiled resources from this program will seed further discovery and validation toward new treatments for Parkinson’s disease.

Study Aims
The Global Parkinson's Genetics Program (GP2) will:

  • Expand current understanding of the genetic architecture of Parkinson’s disease
  • Accelerate discovery and validation of novel disease-causing genetic mutations
  • Provide training and resources to a broad, diverse base of scientists and clinicians

Study Design
This study will engage existing global consortia and cohorts to expand genetic analysis efforts with samples from more than 150,000 people, including those with PD, people at risk for PD, and control volunteers. GP2 will use cutting-edge techniques to analyze samples from people around the world living in or with ancestors from Africa, Asia, Europe and Central and South America. These efforts will transform understanding of the genetic architecture of PD across populations, including those currently underserved in research. The resulting data will aim to provide new biological understanding, greater genetic resolution, better disease risk profiles, and data-driven insight into the full spectrum of PD.

Additionally, GP2 will study rare familial forms of PD with detailed gene discovery efforts toward identification of novel disease-causing mutations.

Lastly, GP2 aims to democratize these efforts. There will be significant focus on training the future generation of genetic researchers and clinicians. The underlying data, analytical processes, and results from GP2 will be made available to the larger research community as quickly as possible, with a minimum of barriers to access and use.

Impact on Diagnosis/Treatment of Parkinson’s Disease
Expanded understanding of the genetic architecture of PD has wide and deep implications for research and care. Findings and data generated from GP2 — new PD-linked genetic associations, relationships between mutations, protective variants, commonalities and differences in the genetics of disease in individuals of diverse ancestry — can help investigators understand who may develop PD, at what time, and to what degree. They can point scientists to new targets against which to develop new treatments to slow, stop, or prevent Parkinson's disease progression. They can help study sponsors design smaller, faster trials with the right drug for the right person at the right time with better methods to assess efficacy. And they can help people living with Parkinson’s and their families understand risk, make lifestyle changes to delay onset, and develop a treatment plan.

Steering Committee
GP2 is a five-year study 
led by Andrew Singleton, PhD, of the National Institutes of Health and a steering committee comprising:
 

  • Cornelis Blauwendraat, PhD; National Institutes of Health, USA
  • Alexis Brice, MD; Brain and Spine Institute, France
  • Ignacio Fernandez Mata, PhD; Cleveland Clinic, USA
  • Brian Fiske, PhD; The Michael J. Fox Foundation, USA
  • Tatiana Foroud, PhD; Indiana University, USA
  • Thomas Gasser, MD; University of Tubingen, Germany
  • John Hardy, PhD; University College London, United Kingdom
  • Peter Heutink, PhD; German Center for Neurodegenerative Diseases, Germany
  • Christine Klein, MD; University of Lubeck, Germany
  • Rejko Kruger, MD; University of Luxembourg, Luxembourg
  • Ken Marek, MD; The Michael J. Fox Foundation, USA
  • Huw Morris, FRCP, PhD; University College London, United Kingdom
  • Michael Nalls, PhD; Data Tecnica International, USA
  • Alastair Noyce, MRCP, PhD; Queen Mary University of London, United Kingdom
  • Alyssa Reimer, BA; The Michael J. Fox Foundation, USA
  • Ekemini A. U. Riley, PhD; Milken Institute Center for Strategic Philanthropy, USA
  • Luba Smolensky, MS; The Michael J. Fox Foundation, USA
  • Enza Maria Valente, MD, PhD; University of Pavia, Italy
  • Nigel Williams, PhD; Cardiff University, United Kingdom
  • Nicholas Wood, MB ChB, PhD; University College London, United Kingdom

ASAP is leveraging The Michael J. Fox Foundation’s grantmaking infrastructure to give awards to various partners for this study. Those with existing potential partner cohorts can email grants@parkinsonsroadmap.org.


Researchers

  • Andrew B. Singleton, PhD

    Bethesda, MD United States


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