To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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CLN3 Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in CLN3, including heterozygous and homozygous R334H, heterozygous and homozygous V330I, and homozygous knockout mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP). Estimated Availability: Q1 2026
CTSB Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in CTSB for heterozygous and homozygous knockout. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP).Estimated Availability: Q1 2026
LysoFix-GBA FQ10 (Lysosomal GCase Probe Yellow)*
Assay
This GCase activity probe is a cell-permeable reporter for GCase activity, fluoresces upon glucocerebrosidase activation, facilitating the detection and monitoring of GBA1 activity. These probes were generated and kindly shared through the MJFF Sponsored Tools Program by David Vocadlo.
LysoFQ-GBA FQ6 (Lysosomal GCase Probe Green)*
Assay
This GCase activity probe is a cell-permeable reporter for GCase activity, fluoresces upon glucocerebrosidase activation, facilitating the detection and monitoring of GBA1 activity. These probes were generated and kindly shared through the MJFF Sponsored Tools Program by David Vocadlo.
Alpha-Synuclein 1-119 Truncation Antibody
Antibody
Rabbit monoclonal antibody specific for human/mouse alpha-synuclein truncated at the 119 residue. The antibody is compatible with slot blot, ELISA, and immunocytochemistry applications.
Alpha-Synuclein 1-122 Truncation Antibody
Antibody
Rabbit monoclonal antibody specific for human/mouse alpha-synuclein truncated at the 122 residue. The antibody is compatible with slot blot and ELISA applications.
LRRK2 N2081D KI Mouse*
Mouse Model
Mice expressing the conserved LRRK2 N2081D variant introduced to exon 41 of the mouse Lrrk2 gene using CRISPR/Cas9 at endogenous levels. Model was donated by Dr. Zhenyu Yue at Mount Sinai School of Medicine, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:037193
BAC-Alpha Synuclein 120*
Mouse Model
Mice conditionally express mutant human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene that produces a C-terminal truncated protein. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028808
BAC-Alpha Synuclein*
Mouse Model
Mice conditionally express wild-type human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028806
Parkin/PINK1 Double KO Rat
Rat Model
Breeding of the CRISPR Parkin KO Sprague Dawley rat with the CRISPR PINK1 KO Sprague Dawley rat to create a line with homozygous deletion of both genes.
Estimated Availability: Mid 2026
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic