The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 58)
Therapeutic Pipeline Program, 2016
Cell replacement therapies for Parkinson's disease (PD) propose to replace the lost dopaminergic neurons in the brain. Transplanted fetal dopamine neurons have provided remarkable recovery in some PD patients and can survive and function for decades. More recently, the field has evolved from this innovative but complex fetal dopamine cell transplantation method t...
Researchers: Ole Isacson, MD, PhD
Research Grant, 2014
Promising Outcomes of Original Grant:
We have established a new procedure to directly convert skin fibroblasts (a type of cell) from pre-clinical models into induced dopaminergic (iDA) neurons. We have provided results showing that iDA neurons are functional and competent to produce and release dopamine and to establish synapses. Moreover, after transplantation in a model of Parkinson's disease, iD...
Researchers: Vania Broccoli, BSc, PhD
Rapid Response Innovation Awards, 2014
Loss of dopaminergic neurons is seen in Parkinson's disease, and transplantation of these neurons can greatly ease symptoms. However, several major drawbacks are associated with transplantation-based therapy, begging for alternatives to treat Parkinson's. Cutting-edge research shows that the fate of cells can be re-engineered in the adult brain, raising the hope of using a patient'...
Therapeutic Pipeline Program, 2014
By the time Parkinson's disease (PD) symptoms appear, typically 60% of neurons in the substantia nigra and their axonal projections (nerve fibers) to the striatum have degenerated. Since targeted axonal outgrowth is limited in the central nervous system, our approach is it to a use tissue engineering strategy to directly restore substantia nigra neurons and their...
Rapid Response Innovation Awards, 2012
Recently, genetic manipulation of human cells from various organs, e.g. skin, enabled direct generation of human nerve cells (so-called induced neurons - iNs) that potentially can be used for cell replacement therapies in neurodegenerative diseases, such as Parkinson's disease (PD). However, it remains unclear whether transplanted human iNs are capable of functionally integrat...
Researchers: Merab Kokaia, PhD