The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 9)
Research Grant, 2018
Genes implicated in Parkinson's disease (PD), such as alpha-synuclein, DJ-1 and LRRK2, strongly influence the effect of environmental toxins, such as pesticide rotenone know to cause Parkinson's. Additionally, rotenone and other PD-relevant environmental toxins can activate proteins implicated in Parkinson's. In this study, we will investigate these associations to better understa...
Researchers: J. Timothy Greenamyre, MD, PhD
Access Data and Biospecimens, 2013
We will investigate the role of environmental factors on likelihood of developing Parkinson's disease (PD) and the severity of the disease in parkinsonism associated with the LRRK2 gene (LRRK2 PD). The effects of environmental factors have not been systematically investigated in LRRK2 PD. We believe that there is a high probably this project will provide important ...
Rapid Response Innovation Awards, 2011
Researchers have reported that early-life inflammation in the brain may increase a risk for development of Parkinson's disease (PD), but the mechanisms involved remain unclear. This study will use a pre-clinical model to test a potential mechanism by which neonatal brain inflammation may result in a chronic inflammatory environment and prolonged exposure to such an environme...
Researchers: Zhengwei Cai, PhD
MJFF Research Grant, 2010
We seek to create and enhance a secure database, accessible by collaborators with customizable, user-friendly, web-based entry for clinical, genetic and pedigree information. This system will also support a native “Global Statistical Test” capability.
Additionally, it will include all the security, workflow and audit features one would expect from a professional clinical data...
Rapid Response Innovation Awards, 2008
Understanding and Modeling the Complexity of Sporadic Parkinson's Disease: Genetic and Environmental Factors
Promising Outcomes of Original Grant:
As mutations in the glucocerebrosidase (GBA) gene are considered to be a risk factor for sporadic Parkinson's disease, we developed a mutant preclinical model with a selective disruption of the GBA gene in midbrain dopamine neurons. As far as one year of age, the majority of mutant models did not display any behavioral impairment or dopaminergic neurodegenerat...