The Michael J. Fox Foundation continually strives to communicate our scientific progress -- at meetings, as well as through peer-reviewed scientific publications.
May 20, 2008
Background: In a pre-clinical model of Parkinson disease (PD), intrastriatal infusion of an adeno-associated viral (AAV) vector containing the human aromatic l-amino acid decarboxylase (hAADC) gene results in robust gene expression. After gene transfer, low doses of systemically administered l-dopa are converted to dopamine in the transduced striatal neurons, resulting in behavioral improvement without the side effects typically associated with higher doses of ...Read More