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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2020
    Anle138b Clinical Phase 1 Studies: Food Effect, Safety and Tolerability as well as Pharmacokinetics in Parkinson´s Disease Patients

    Study Rationale: 
    Clumps of the protein alpha-synuclein, called Lewy bodies, are a hallmark of Parkinson’s disease and a promising target for therapeutic development. Anle138b is a drug-like compound...

  • Target Advancement Program, 2020
    The Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein

    Study Rationale:
    There is growing interest in the anti-inflammatory properties of cannabis-related compounds as a potential therapy for Parkinson’s disease (PD). Cannabis, or marijuana, acts on...

  • Research Grant, 2020
    Targeting TNFR2 in a Model of Parkinson’s Disease

    Study Rationale:
    In previous research, we demonstrated that the protein tumor necrosis factor receptor 2 (TNFR2) plays an essential role in reducing inflammation in the peripheral and central nervous...

  • Therapeutic Pipeline Program, 2020
    Development of Novel Parkin Activators

    Study Rationale:
    In Parkinson’s disease, brain cells die when their mitochondria (structures that create energy for the cells) are damaged and cannot be removed efficiently. An enzyme called parkin...

  • Target Advancement Program, 2020
    Evaluating the Role of Natural Killer Cells in Parkinson's Pathology

    Promising Outcomes of Original Grant:
    Our original study investigated whether immune cells called human natural killer (NK) cells play a protective role on the nervous system in Parkinson’s disease....

  • Research Grant, 2020
    Identification of Therapeutic Circuits to Address Anxiety and Depression Symptoms in Parkinson’s Disease

    Study Rationale: Parkinson’s disease patients often experience depression and anxiety. Addressing these non-motor symptoms has not been the focus of Parkinson’s disease research though psychiatric...

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