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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Alpha-Synuclein Imaging, 2020
    PET Imaging Probe Development for Alpha-synuclein
    Ken Griffin Alpha-synuclein Imaging Competition Logo

    Study Rationale:
    Alpha-synuclein is a protein that can clump to form Lewy bodies and lewy neurites, which are a hallmark of Parkinson's disease. Being able to identify these clumps in living patients...

  • Alpha-Synuclein Imaging, 2020
    Alpha-Synuclein PET Tracer Discovery
    Ken Griffin Alpha-synuclein Imaging Competition Logo

    Study Rationale:
    The discovery of new treatments for Parkinson’s disease has been slowed by the time it takes to answer the question “did a drug work” in a clinical trial. Tests that can assess...

  • Alpha-Synuclein Imaging, 2020
    Optimization of Morphomer-Based Alpha-synuclein PET Tracers
    Ken Griffin Alpha-synuclein Imaging Competition Logo

    Study Rationale:
    The team at AC Immune has discovered a variety of compounds that can bind to a specific Parkinson’s disease-associated form of the protein alpha-synuclein. AC Immune has previously...

  • Therapeutic Pipeline Program, 2020
    Anle138b Clinical Phase 1 Studies: Food Effect, Safety and Tolerability as well as Pharmacokinetics in Parkinson´s Disease Patients

    Study Rationale: 
    Clumps of the protein alpha-synuclein, called Lewy bodies, are a hallmark of Parkinson’s disease and a promising target for therapeutic development. Anle138b is a drug-like compound...

  • Target Advancement Program, 2020
    The Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein

    Study Rationale:
    There is growing interest in the anti-inflammatory properties of cannabis-related compounds as a potential therapy for Parkinson’s disease (PD). Cannabis, or marijuana, acts on...

  • Research Grant, 2020
    Targeting TNFR2 in a Model of Parkinson’s Disease

    Study Rationale:
    In previous research, we demonstrated that the protein tumor necrosis factor receptor 2 (TNFR2) plays an essential role in reducing inflammation in the peripheral and central nervous...

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