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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Biomarkers of Protein Handling/Autophagy, Exosomes and Lipid, 2019
    Measuring Lipids in iPSC-derived Dopamine Neurons to Identify Parkinson’s Biomarkers

    Study Rationale:
    Changes in lipid metabolism have been strongly associated with Parkinson’s disease (PD). Lipids have the potential to be important biomarkers for PD, but the lack of appropriate tools...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    GBA Sequencing and Detection of Mutations, Deletions, Insertions and Recombinations with the GBA Pseudo Gene

    Study Rationale:
    Mutations in the GBA gene are the most common genetic cause of Parkinson’s disease. This gene has a nearby pseudogene, which is a genetic material that is very similar to the original...

  • Alpha-synculein Biology and Therapies, 2019
    Chaperones of Alpha-synuclein for Membrane Fusion Involved in Synaptic Transmission

    Study Rationale:
    Abnormal accumulation of the protein alpha-synuclein is a pathological hallmark of Parkinson’s disease (PD). We and others have evidence that aggregated alpha-synuclein could harm...

  • Research Grant, 2019
    Discovery and Development of Parkin Activators as Therapies for Parkinson’s Disease

    Study Rationale:
    Impaired mitochondria are a shared feature of Parkinson's disease (PD). Thus restoration of mitochondrial function offers a therapeutic avenue to slow the progression of PD. Parkin...

  • Non-pharmacological Interventions for Gait and Balance, 2019
    Wearable Airbag Technology to Mitigate Falls in Individuals with Parkinson’s Disease

    Study Rationale:
    People with Parkinson's disease may fall due to issues with gait and balance or weak muscles. Falling can result in serious injuries, such as a broken hip. After a fall, people may...

  • Non-pharmacological Interventions for Gait and Balance, 2019
    StandingTall-PD. An engaging neuro-rehabilitation program using eHealth technologies to reduce step-time variability, prevent freezing of gait and falls, and enhance independence in people with Parkinson's disease: A placebo randomized controlled trial

    Study Rationale:
    People with Parkinson's disease often experience falls, which can have serious consequences. Falls may be caused by gait impairments, postural instability and freezing of gait (FOG)...

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