The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2017Neuroprotective Effects of Endosulfine-alpha in Parkinson's Disease
Study Rationale:
Evidence suggests that alpha-synuclein can cause neuron death in Parkinson's disease (PD) by forming clusters (or aggregates) on the surface of small structures inside the cell called... -
Target Advancement Program, 2017Validation of USP30 as a Therapeutic Target for Parkinson's Disease Modification
Study Rationale:
Mitochondria provide energy for neurons to function and survive. Evidence suggests that individuals with Parkinson's disease (PD) have poorly functioning mitochondria, such that the... -
Target Advancement Program, 2017Farnesoid X Receptor to Reduce Neuroinflammation
Study Rationale:
Although the precise mechanism(s) for neurodegeneration in Parkinson's disease (PD) is unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we... -
Therapeutic Pipeline Program, 2017Small-Molecule Inhibitor of Alpha-Synuclein Propagation in the Treatment of Parkinson's Disease
Study Rationale:
The notion of misfolded alpha-synuclein (alpha-syn) aggregates moving from neuron-to-neuron is a mechanism that is gaining widespread acceptance as a central mechanism in the... -
Therapeutic Pipeline Program, 2017Pre-clinical Development of LBT-3627, a Potential Neuroprotective and Anti-inflammatory Therapy for Parkinson's Disease
Study Rationale:
Adaptive and innate immune responses play important roles in neuroinflammation and can be harnessed to improve outcomes in Parkinson's disease (PD). Daily administration of LBT-3627... -
Improved Biomarkers and Clinical Outcome Measures, 2017Using Automatic Acoustic Speech Analysis and REM Sleep Behavior Disorder to Detect Individuals at High Risk of Parkinson's Disease and Other Alpha-synucleinopathies
Study Rationale:
Speech is an important indicator of motor function and movement coordination and can be extremely sensitive to the progression of neurologic diseases. The aim of this project is to...
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Our funding programs support basic, translational and clinical research from academia and industry.