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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2021
    Proof of Concept and Translational Validation of USP30 to Offset Dysfunction in the PRKN Pathway

    Study Rationale: 
    USP30 is an enzyme which acts in the opposite way to Parkin (PRKN), a gene linked to young-onset Parkinson’s disease (PD). Mutations in the PRKN gene impact mitochondria (the cell’s...

  • Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2021
    Reprogramming the Brain’s Non-neuronal Support Cells to Generate Functional Dopamine-producing Neurons

    Study Rationale:
    We have recently demonstrated that a method for converting supportive, non-neuronal brain cells into functional dopamine-producing neurons leads to the complete reversal of symptoms in...

  • PIPETTE 4R Tau and Alpha-Synuclein PET Tracer Development, 2021
    San Antonio Ligand Consortium (SALC)

    Study Rationale:
    The development of alpha-synuclein and 4-repeat tau (4RT) positron-emission tomography (PET) imaging agents would benefit people with Parkinson’s disease (PD), progressive supranuclear...

  • Therapeutic Pipeline Program, 2021
    Using Virtual Reality to Understand and Treat Freezing of Gait

    Study Rationale:
    Freezing of gait, an episodic inability to initiate movement, is a leading reason for loss of independence in Parkinson’s disease (PD). Despite its prevalence, we lack an effective...

  • Research Grant, 2021
    Tagging Genes Associated with Parkinson’s Disease Using the Gene-editing CRISPR Tool

    Study Rationale:
    Parkinson’s disease (PD) is caused, in part, by genetic alterations that produce defective proteins or perturb normal pathways in the brain. To determine how these alterations lead...

  • Target Advancement Program, 2021
    Pathogenic Mechanisms for Auxilin-mediated Parkinson's Disease

    Study Rationale:
    Parkinson’s disease (PD) is a prevalent neurodegenerative movement disorder. Several genetic mutations that cause PD have been identified in patients. One such mutation targets...

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