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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2022
    Restoring the Blood-brain Barrier to Prevent Dissemination of Alpha-synuclein and Progression of Parkinson’s Disease

    Study Rationale: The cells of the brain are physically separated from the rest of the body by the blood-brain barrier, a network of blood vessels that restricts transfer of materials from the...

  • Research Grant, 2022
    Using the Emergence of New Symptoms as a Measure for Parkinson’s Disease Progression in Clinical Trials

    Study Rationale: Studies suggest that as Parkinson’s disease (PD) progresses, new areas of the brain fall prey to PD pathology. If this is the case, PD progression may be best assessed by tracking the...

  • Summer 2022 RFP: Accelerating the Translation of Parkinson's Disease Therapies, 2022
    Validation of a Novel Mitochondrial Drug Target for Parkinson’s Disease

    Study Rationale: Mitochondria provide cells with energy, but they also help regulate the flow of large amounts of calcium ions that flood neurons when they are active. In Parkinson’s disease (PD)...

  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Evaluating an Insulin-degrading Enzyme as a Novel Therapeutic Target for Parkinson’s Disease

    Study Rationale: In Parkinson’s disease (PD), the clumping of the protein alpha-synuclein in the brain causes the death of neurons. Recent studies have shown that the insulin-degrading enzyme (IDE)...

  • Research Grant, 2022
    Evaluation of a Monitoring System Based on a Wearable Sensor for Improving Swallowing and Saliva Control in Parkinson’s Disease

    Study Rationale: Trouble with swallowing and increased drooling are common issues for people with Parkinson’s disease (PD). These oral symptoms occur in up to 80% of cases. Our prior work showed that...

  • Research Grant, 2022
    Performing a First-In-Human Study of a Retinal Tracer For Alpha-synuclein in Parkinson's Disease

    Study Rationale: Like the brain, the retina is part of the central nervous system. We therefore aim to develop a new and simple way to diagnose Parkinson’s disease (PD) via examination of the eye. To...

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