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The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Alpha-Synuclein Imaging, 2020PET Imaging Probe Development for Alpha-synuclein
Study Rationale:
Alpha-synuclein is a protein that can clump to form Lewy bodies and lewy neurites, which are a hallmark of Parkinson's disease. Being able to identify these clumps in living patients... -
Alpha-Synuclein Imaging, 2020Alpha-Synuclein PET Tracer Discovery
Study Rationale:
The discovery of new treatments for Parkinson’s disease has been slowed by the time it takes to answer the question “did a drug work” in a clinical trial. Tests that can assess... -
Alpha-Synuclein Imaging, 2020Optimization of Morphomer-Based Alpha-synuclein PET Tracers
Study Rationale:
The team at AC Immune has discovered a variety of compounds that can bind to a specific Parkinson’s disease-associated form of the protein alpha-synuclein. AC Immune has previously... -
Therapeutic Pipeline Program, 2020Anle138b Clinical Phase 1 Studies: Food Effect, Safety and Tolerability as well as Pharmacokinetics in Parkinson´s Disease Patients
Study Rationale:
Clumps of the protein alpha-synuclein, called Lewy bodies, are a hallmark of Parkinson’s disease and a promising target for therapeutic development. Anle138b is a drug-like compound... -
Target Advancement Program, 2020The Role of Cannabinoid Receptor 2 in Inflammatory Responses Triggered by Alpha-synuclein
Study Rationale:
There is growing interest in the anti-inflammatory properties of cannabis-related compounds as a potential therapy for Parkinson’s disease (PD). Cannabis, or marijuana, acts on... -
Research Grant, 2020Targeting TNFR2 in a Model of Parkinson’s Disease
Study Rationale:
In previous research, we demonstrated that the protein tumor necrosis factor receptor 2 (TNFR2) plays an essential role in reducing inflammation in the peripheral and central nervous...
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Our funding programs support basic, translational and clinical research from academia and industry.