Osmolex ER, an extended-release formulation of Symmetrel (immediate-release amantadine), was approved in 2018 by the U.S. Food and Drug Administration (FDA) to treat Parkinson's motor symptoms (tremor, slowness and stiffness). It works on the dopamine and glutamate brain chemical systems. Osmolex ER is taken once a day, in the morning.
In early Parkinson's or with mild symptoms, Osmolex ER may be an option to lessen motor symptoms. The once-a-day dosing may be beneficial for some.
Cons and Complications
The most common potential side effects include insomnia, nausea, dizziness and purple-red blotchy spots on the skin. In people with kidney problems, the dose may need to be decreased.