Participate in PPMI: Focus on Genetics
Over the past decade, studies of the genetics of Parkinson’s disease have revolutionized the pursuit of a “disease-modifying” treatment — a therapy that can slow or stop the progression of PD. Studying people with Parkinson’s and their families is essential to help researchers identify genetic traits that may contribute to the onset and progression of PD.
The Parkinson's Progression Markers Initiative (PPMI) is The Michael J. Fox Foundation's flagship biomarkers study seeking to learn more about the genetics of Parkinson's disease. PPMI is currently studying the connection between PD and having a mutation in either the LRRK2 or GBA gene — both are promising targets of PD research.
How you can participate
Whether you have PD or not, you may be eligible to receive genetic counseling and testing at no cost to determine if you qualify to participate in PPMI.
NEVER BEEN GENETICALLY TESTED?
PPMI is seeking individuals who meet either of the following criteria:
- People with Parkinson's who are of Eastern European (Ashkenazi) Jewish, North African Berber, or Basque ancestry.
- Individuals without PD who are related to someone with PD AND who are of Eastern European (Ashkenazi) Jewish, North African Berber, or Basque ancestry.
Have you already been tested?
If you know you have a LRRK2 or GBA mutation:
Select PPMI sites are also studying the connection between Parkinson’s and the SNCA gene. If you have been tested and know that you have a mutation in your SNCA gene, contact a PPMI site.
Learn More About the Genetic Testing Process in PPMI
Take the Survey: Take PPMI's brief online survey to find out if you may be eligible to receive genetic counseling and testing for the purposes of PPMI.
Get a Genetic Test: Eligible volunteers may be mailed a genetic testing kit requiring a saliva sample to determine whether or not there is a mutation in your LRRK2 or GBA gene. Your saliva sample is sent to a central laboratory for testing.
Talk with a Genetic Counselor: You will be contacted by a genetic counselor to review your test results together. You will also discuss your personal and family medical history and the genetics of Parkinson's disease. Some volunteers may be invited to participate in additional tests and evaluations.
If you are interested in receiving free genetic counseling and testing for the LRRK2 and GBA mutations for the purposes of participating in PPMI, fill out our questionnaire or call (888) 830-6299.
|PPMI Clinical Sites|
|City/State||Site Name||Local Site Phone Number|
|Athens, Greece||Attikon University Hospital||+30 2105832493|
|Atlanta, GA||Emory University||404-728-6944|
|Barcelona, Spain||Hospital Clinic de Barcelona||+34 646699750|
|Baltimore, MD||Johns Hopkins University||410-955-2954|
|Birmingham, AL||University of Alabama at Birmingham||877-836-8108|
|Boca Raton, FL||Parkinson's Disease and Movement Disorders Center of Boca Raton||(561) 392-1818 x 6|
|Boston, MA||Boston University Medical Center||617-638-7737|
|Chicago, IL||Northwestern University||(312) 503-0755|
|Cincinnati, OH||University of Cincinnati||513-558-6517|
|Cleveland, OH||Cleveland Clinic||216-444-1134|
|Houston, TX||Baylor College of Medicine||713-798-3951|
|Innsbruck, Austria||University of Innsbruck||+43 512 504 81553|
|Kassel, Germany||Paracelsus-Elena Klinik||+49 561 6009 272|
|London, UK||Imperial College London||+44 203 311 1714|
|New Haven, CT||Institute of Neurodegenerative Disorders||203-401-4332|
|New York, NY||Columbia University Medical Center||212-305-9183|
|New York, NY||Beth Israel Medical Center||212-844-8713|
|Paris, France||Pitié-Salpêtrière Hospital||+33 1 42 16 57 67|
|Philadelphia, PA||University of Pennsylvania||215-829-7374|
|Portland, OR||Oregon Health Sciences University||503-494-0276|
|Rochester, NY||University of Rochester||585-341-7515|
|Salerno, Italy||University of Salerno||+39 340 519 2659|
|San Diego, CA||University of California at San Diego||858-622-5800|
|San Sebastian, Spain||Hospital Universitario Donostia||+34 943007027|
|Seattle, WA||University of Washington / VA Puget Sound||206-277-5087|
|Sun City, AZ||Banner Sun Health Research Institute||623-832-5468|
|Sunnyvale, CA||The Parkinson’s Institute||408-542-5664|
|Sydney, Australia||Macquarie University||+61 298-123-720|
|Tampa, FL||University of South Florida||813-396-0768|
|Tel Aviv, Israel||Tel Aviv Sourasky Medical Center||+972 3-6973014|
|Trondheim, Norway||Norwegian University of Science and Technology||+47 911 08 377|
|Tuebingen, Germany||University of Tuebingen||+49 7071 2983272|
Need more info?
Learn more about PPMI genetics by calling (888) 830-6299.