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RESEARCH TOOLS

The Michael J. Fox Foundation is committed to eliminating challenges to finding a cure for Parkinson’s disease. We identify needed research tools with the potential to bolster efforts throughout the field and work with appropriate partners to engineer these tools at a high level of quality. Once we have developed them, we create (or leverage existing) practical distribution channels that remove hurdles to their widespread use by academic and industry researchers.

View our complete research tool catalogueview our complete research tool catalogue

 

Reagents

DNA Plasmids

The Foundation is working with a repository to create a library of DNA plasmids that can be utilized to examine a number of genes implicated not only in PD but in PD-relevant pathways to examine them in a variety of cell systems.

Learn More About DNA PlasmidsView Addgene’s Entire Collection of Plasmids Related to Parkinson’s Disease

View Addgene’s Entire Collection of Plasmids Related to Parkinson's DiseaseView Addgene’s Entire Collection of Plasmids Related to Parkinson’s Disease

 

Viral Vectors

The Foundation is developing a resource of viral vectors to deliver Parkinson’s disease genes of interest for use in cellular and in vivo studies.

View available viral vectorsview our viral vector listing

 

Proteins

The Foundation recognizes the utility of protein reagents as critical for a number of applications, including for use as standards in assays. Given this need, MJFF is working to generate a number of reagents around key PD targets.

Learn more about protein reagentsLearn More About Protein Reagents

 

Antibodies

MJFF is creating high-quality antibodies against critical PD proteins for use by the research and drug development community. Antibodies can be used to interrogate PD proteins of interest in a number of methodological platforms.

Learn more about antibodiesLearn More About Protein Reagents

 

Assays

Evaluation of changes that occur in biological samples is the cornerstone of biomarker identification. MJFF is working to leverage antibodies generated by the Foundation, as well as those that are commercially available, to develop assays that can be used to better quantify levels of PD proteins of interest in biological samples.

Learn more about assaysview our antibody listing

 

Research Models

Cellular Models

A homogenous population of (immortalized) cells that can be interrogated and assayed is a critical tool for scientists at the bench. Cell lines facilitate the analysis of protein structure, function and enable scientists to investigate changes in cellular homeostasis upon administration of compounds of interest and/or expression of exogenous targets (protein/nucleic acid). MJFF is working with a number of partners to develop these valuable resources for investigators.

Learn more about cellular modelsLearn More About Cellular Models

Learn more about MJFF-supported fibroblast lines available at CoriellLearn More About MJFF-Supported Fibroblast Lines Available at Coriell

Learn More About MJFF-Supported iPSC Lines Available at CoriellLearn More About MJFF-Supported iPSC Lines Available at Coriell

 

Animal Models

The Foundation has invested significant effort into producing animal models to further advance our understanding of Parkinson’s disease and provide effective translatable tools for drug discovery.

View available animal modelsview our animal models listing

 

Genetic Resources

PDGene Database

The Foundation has helped launch the PDGene database, a comprehensive, unbiased and regularly updated field synopsis of genetic association studies performed in Parkinson’s disease.

View the PDGene websiteview pd gene site

 

Data & Samples

Clinical Data and Biologic Sample Resources

MJFF has supported pre-clinical and clinical efforts that have generated valuable tissue and biosample resources for the research community. Resources include tissue from post-mortem human brain and whole-body donation programs as well as preclinical research PD models. We also have made available clinical data and biosamples from current and previous clinical studies and trials. Researchers can access these resources through a variety of mechanisms and in some cases seek specific MJFF funding to use these resources. See our MJFF Biosample and Tissue Resources for information about programs supporting work with our sample resources. You can also access and download clinical data and request access to biosamples from PPMI, our large-scale, international biomarker study.

View the PPMI websiteview pd gene site

Tools Priority Area

Learn more about why we’re investing in research tools and our 2014 priorities.

Read more about the Priority MORE

 

Accelerate Your Research

Search open funding programs MORE

 

Access Research Tools

Select from pre-clinical models, reagents, research data and more.

learn more MORE

 

Research Tools Consortium

MJFF is working with industry to better understand existing tools and to develop new ones.

Read more about the Consortium MORE

 

Conducting a Trial?

Learn more about best practices when it comes to recruitment and retention.

view our clinical trial resources MORE

 

Connect With Other Researchers

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