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Targeting Serotonin Transporters for the Treatment of L-DOPA-induced Dyskinesia
… treatment leads to abnormal involuntary movements known as dyskinesia. In recent years, compelling evidence has … play an integral role in expression of levodopa-induced dyskinesia. Preclinical studies of the current project will …
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AVP-923 for Levodopa-induced Dyskinesia in Parkinson's Disease
… levodopa treatment, can cause abnormal movements called dyskinesia. Previous studies in PD and in laboratory models showed that dextromethorphan can reduce dyskinesia at doses that are well tolerated. This study will …
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Development of L-745,870, a Selective D4 Receptor Antagonist, for the Treatment of Levodopa-induced Dyskinesia
… that L-745,870 reduces the problem of levodopa-induced dyskinesia in pre-clinical models with parkinsonism. We … of L-745,870 and move it forward as a treatment for dyskinesia in PD. Project Description: We have …
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Evaluation of Cortical Resonant Oscillations as a Novel Target for Treatment of Dyskinesia
… that when parkinsonian models experience levodopa-induced dyskinesia this is always associated with high-frequency … with the oscillation in order to reduce levodopa-induced dyskinesia. Because activity in one part of the brain often …
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The Nur77/RXR Transcriptional Complex as a New Target in L-Dopa-induced Dyskinesia Treatment
… processes such as those occurring in levodopa-induced dyskinesias. We have previously shown that two transcription … Nur77 and RXR can be targeted to reduce levodopa-induced dyskinesias. Project Description: To demonstrate the role of …
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Targeting M4 Muscarinic Receptors for the Treatment of Levodopa-induced Dyskinesia
… Study Rationale: Levodopa-induced dyskinesia is thought to stem from sustained stimulation of … adjunct therapies that alleviate levodopa-induced dyskinesia. Next Steps for Development: Any insights gained …