The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 20)
Research Grant Supplement, 2015
Promising Outcomes of Original Grant:
The objective of our Rapid Response Innovation Awards-supported project was to identify the parkin domain that interacts with Stomatin-like protein 2 (SLP-2), a mitochondrial protein we recently identified as being able to interact with parkin. We believe this interaction is important for maintaining healthy mitochondria and thus set out to examine the effects ...
Rapid Response Innovation Awards, 2014
Defects in mitochondria (the "powerhouse" of the cell) are implicated in Parkinson's disease (PD), and the protein parkin is known to be involved in controlling mitochondrial health. An important step for better understanding how parkin does this is to get a more comprehensive understanding of which proteins interact with parkin and how they support its protective function on m...
Improved Neuromodulation Approaches, 2014
The side effects of deep brain stimulation (DBS) in Parkinson's disease are related to overstimulation of the brain target structure and neighboring regions. This clinical study seeks to improve outcomes by controlling the direction of the electrical current in the brain using a novel directional DBS electrode lead. This approach offers more precise current delivery, require...
Researchers: André Mercanzini, PhD
Rapid Response Innovation Awards, 2011
Gene therapy may offer effective treatments to patients. Delivering genes to cells in the body has the potential of letting the patient's cells treat themselves. In the case of PD, delivering the gene for glial-cell derived neurotrophic factor (GDNF) into the brain has the potential to protect brain cells in PD patients. However, if this factor is produced for very long perio...
Researchers: Cecilia Lundberg, PhD
Levodopa remains the gold-standard treatment for Parkinson's disease, unfortunately chronic treatment leads to abnormal involuntary movements known as dyskinesia. In recent years, compelling evidence has suggested that serotonin neurons play an integral role in expression of levodopa-induced dyskinesia. Preclinical studies of the current project will test whether modulation of...
Researchers: Christopher Bishop, PhD