The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 121)
Improved Biomarkers & Clinical Outcome Measures, 2017
MicroRNAs (miRs) are short RNA molecules (messengers that carry genetic information to DNA) that block protein expression by crossing with hundreds of mRNA targets. Neuron-restricted miRs regulate specific aspects of neuron development and function, unlike broadly expressed miRs that control house-keeping processes. Deregulation of neuron miR expression leads to brain dysfunction....
Therapeutic Pipeline Program, 2016
Blocking Inflammasome-induced Neuroinflammation in Parkinson's Disease with a Potent, Orally Available Small Molecule
Our brains are full of immune cells called microglia, which fight infections and clear the brain of toxic products. In Parkinson's disease, these cells are constantly active, leading to brain inflammation that damages neurons (nerve cells). Evidence of this inflammation is found in the blood and brains of Parkinson's patients. To fight this damage, we developed small molecules (sui...
Researchers: Matthew Allister Cooper, PhD
Research Grant, 2016
GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221 carrying a GBA mutation) and 20,868 longitudinal study visits conducted in England, the Netherlands, France, Canada and the United States. This study found that GBA mutations hasten the longitudinal pro...
Target Optimization Awards Spring 2016, 2016
Upregulation of Autophagy by Tet3-mediated 5-methylcytosine oxidation - Relevance to Parkinson's Disease
An abnormally folded version of the protein alpha-synuclein forms characteristic clumps (Lewy bodies) in nerve cells in Parkinson's disease (PD). One possible reason for this is an age-related decrease in enzymes that degrade (break down) alpha-synuclein and are involved in the lysosome-autophagy system (LAS). During aging, changes in DNA methylation (the process of regulating gen...
Target Validation Awards Spring 2016, 2016
Many scientific studies have shown that one of the major causes of Parkinson's disease (PD) is the accumulation of a protein named alpha-synuclein in a certain type of neurons. When these neurons produce high quantities of this protein, they die and their loss triggers a dysfunction of the brain that is responsible for the motor symptoms of PD; however, the reasons for this excessi...