The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 131)
Research Grant, 2018
This study aims to produce data that will help to understand the molecular processes and networks underlying Parkinson's disease (PD). In this study, we will use cells from people who participated in the Parkinson's Progression Markers Initiative (PPMI), our large-scale, international biomarker study.
Research approaches including complex genetics will generate critica...
Researchers: Andrew B. Singleton, PhD
Mitochondrial Biomarkers Program, 2018
Biomarkers, or objective measures, of Parkinson's disease (PD) could help identify individuals at risk of PD and predict disease progression. According to recent studies, changes in DNA, such as hydroxymethylation -- the attachment of chemical hydroxymethyl -- can serve as PD biomarkers. It is also known that DNA changes in mitochondria -- powerhouses of the cells -- can affect th...
Health and longevity of brain cells depends on the efficiency of their waste removal process, known as autophagy or self-eating. Cells use autophagy to get rid of unwanted protein clumps and broken mitochondria -- cell's energy generators -- among other waste. Accumulation of damaged mitochondria and protein clumps inside the cell are a hallmark of neurodegenerative diseases, such...
Researchers: Erika L.F. Holzbaur, PhD
Improved Biomarkers and Clinical Outcome Measures, 2017
MicroRNAs (miRs) are short RNA molecules (messengers that carry genetic information to DNA) that block protein expression by crossing with hundreds of mRNA targets. Neuron-restricted miRs regulate specific aspects of neuron development and function, unlike broadly expressed miRs that control house-keeping processes. Deregulation of neuron miR expression leads to brain dysfunction....
Research Grant, 2017
Drawing on the Parkinson's Progression Markers Initiative (PPMI) Data to Link Changes in the PINK1/Parkin Genes with Parkinson's Disease
Two proteins, PINK1 and Parkin, prevent cell death by breaking down damaged mitochondria, cell's energy generators. This process is known as mitophagy. Mutations in PINK1/Parkin genes -- genetic changes that render these proteins unable to perform their function -- cause Parkinson's disease (PD). Failure to remove damaged mitochondria from the cell can start or speed up the course...