The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 60)
Research Grant, 2018
There is a pressing need for Parkinson's disease (PD) biomarkers -- objective measures of disease -- that will enable early and accurate diagnosis and allow to track disease progression and therapeutic improvement. We have developed a new mathematical method to characterize PD-related brain networks. This method is based on a mathematical analysis of data collected via resting sta...
Biomarkers Across Neurodegenerative Diseases, 2018
This study builds on two recent discoveries in neuroscience: first, the brain is organized in large-scale networks of nerve cells; and second, the clumps of alpha-synuclein, amyloid and tau -- proteins implicated in Parkinson's disease (PD) and Alzheimer's disease (AD) -- can spread from nerve cell to nerve cell, like infection.
Parkinson's and Alzheimer's affect diffe...
Researchers: Alain Dagher, MD
Improved Biomarkers and Clinical Outcome Measures, 2017
Dopamine Buffering Capacity Measured by phMRI as a Novel Biomarker of Disease Progression in Parkinson's Disease
This project will test a new idea for measuring the severity of Parkinson's disease (PD). The brain acts as if it can store each dose of levodopa (L DOPA) for a short period of time and lets it "leak" into the brain when needed. This levodopa reservoir appears to get "leakier" as PD progresses, contributing to a gradually briefer benefit from each dose of the drug. The new idea we...
Researchers: Kevin J. Black, MD
Computational Science, 2017
Because Parkinson's disease (PD) affects people around the world regardless of their ethnicity or place of residence, research to find a cure for Parkinson's is truly an international effort. We aim to support this effort by creating the largest international database of brain images from people with and without PD. We will search these images for variations in the brains of peopl...
Researchers: Neda Jahanshad, PhD
Improved Biomarkers and Clinical Outcome Measures, 2016
Amyloid fibrils play a key role in Parkinson's disease (PD). Studying their formation from self‐assembled aggregates (protein clumps) would help aid the development of a valuable diagnostic tool. Despite progress in understanding these processes in a test tube, visualization through an imaging approach has not yet been fully achieved. We will develop a contrast agent with protectiv...
Researchers: Leif Schröder, Dr. rer. nat.