The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
FUNDED GRANTS ( 40)
Target Advancement Awards, 2017
Homeostasis (balance) of mitochondria, the powerhouses of cells, is crucial for longevity. Accumulation of damaged mitochondria is toxic for cells, which is believed to be one of the triggers that leads to neurodegeneration in Parkinson's disease (PD). We plan to investigate the cellular mechanisms of a mitochondrial safeguard, the protein kinase (enzyme that modifies proteins) PIN...
Researchers: Marius K. Lemberg, Dr Sc
Therapeutic Pipeline Program, 2017
The Parkin protein (encoded by the PARK2 gene that is linked to Parkinson's), has been shown to exert potent neuroprotective effects that could potentially be used to treat Parkinson's disease (PD). Cellivery has developed a recombinant cell-permeable Parkin protein (iCP-Parkin) using macromolecule intracellular transduction technology (MITT), a technique that can deliver active Pa...
Research Grant, 2017
Promising Outcomes of Original Grant:
Mitophagy is a cellular process during which damaged mitochondria, or energy generators, are broken down. Mitophagy has been suspected to malfunction in Parkinson's disease (PD), but evidence to support this does not exist. Using our new pre-clinical model, we have proven that mitophagy does take place in healthy brain cells but does not require a series of che...
Researchers: Ian G. Ganley, PhD
Research Grant, 2017
Drawing on the Parkinson's Progression Markers Initiative (PPMI) Data to Link Changes in the PINK1/Parkin Genes with Parkinson's Disease
Two proteins, PINK1 and Parkin, prevent cell death by breaking down damaged mitochondria, cell's energy generators. This process is known as mitophagy. Mutations in PINK1/Parkin genes -- genetic changes that render these proteins unable to perform their function -- cause Parkinson's disease (PD). Failure to remove damaged mitochondria from the cell can start or speed up the course...
Target Validation Awards Spring 2016, 2016
Role of PINK1 and Parkin in Innate Immunity: Crosstalk between Mitochondrial Dysfunction and NLRP3 Inflammasome Signaling
Mitochondrial dysfunction and neuroinflammation play major roles in Parkinson's disease (PD). Overactivation of the inflammasome (innate immune system receptor) signaling complex NLRP3 is suspected to contribute to dopaminergic neurodegeneration. The PD-associated proteins PINK1 and Parkin jointly regulate mitochondrial quality control pathways and have also been linked to innate i...
Researchers: Olga Corti, PhD