Validation of the Movement Disorders Societyís Clinical Criteria of Parkinsonís Disease
Research Grant, 2014
Diagnosis of Parkinsonís disease (PD) and other causes of parkinsonism is not always an easy task for physicians. An accurate diagnosis, however, is an essential aspect of care for people with Parkinsonís and of research trials, where the inclusion of incorrectly diagnosed patients can result in trial failure. Recently, the International Parkinson and Movement Disorders Society (MDS) created new standard diagnostic criteria to improve the reliability of diagnosis. In this study we will test the validity of these criteria for diagnosing PD.†
We will assess the diagnostic value of the new MDS criteria and test them against the diagnosis of an expert and the previously established UK Brain Bank Criteria.
The MDS criteria will be tested on 600 patients from 10 centers on different continents. After a phase of cognitive pretesting, during which the criteria are applied to a small group of people with PD, patients with a diagnosis of parkinsonism will be evaluated both by a clinical expert and a resident applying the new criteria as well as the UK Brain Bank Criteria. In a follow-up visit two years later, the diagnoses will be reevaluated.
Impact on Diagnosis/Treatment of Parkinsonís Disease: † † † † † ††
These new criteria have the potential to facilitate and standardize the diagnosis of Parkinsonís disease to detect patients with PD earlier and more reliably for earlier treatment and accurate involvement in trials.
Next Steps for Development:
Provided that the new MDS criteria prove to be superior to former diagnosis of Parkinsonís disease, these criteria will be internationally implemented for clinical routine and research.
Assistant Professor at McGill University/Research Institute of the McGill University Health Centre
Location: Montreal, Quebec, Canada
Professor, Department for Neurodegenerative Diseases at Centre of Neurology and Hertie-Institute for Clinical Brain Research, University Hospital Tuebingen
Location: Tuebingen, Germany